n3 PUFA and Muscle-disuse Atrophy in Older Women (NCT03808519) | Clinical Trial Compass
TerminatedNot Applicable
n3 PUFA and Muscle-disuse Atrophy in Older Women
Stopped: Funding
Canada8 participantsStarted 2019-02-18
Plain-language summary
This study will examine the influence of n3 PUFA supplementation on the rate of muscle atrophy in older women undergoing 1 week of unilateral limb immobilization. Assessments in skeletal muscle strength and skeletal muscle volume will also me made before, after and in recovery from immobilization.
Who can participate
Age range55 Years – 75 Years
SexFEMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Female
* Aged 55 - 75 years old
* non-smoking (for at least 2 years)
* \> 5 years post-menopausal
* Body mass index (BMI) between 22 and 33 kg/m2
* Mini-Mental State Exam (MMSE) score \> 20
* Acceptable medications include: Angiotensin Converting Enzyme (ACE), Beta-Blockers, Acetylsalicylic Acid, Calcium Channel blockers, Depression/Anxiety meds, Bisphosphonates (Fosamax®, Didrocal®, Actonel®, Aclasta®).
Exclusion Criteria:
* Any concurrent medical, orthopedic, or psychiatric condition that, in the opinion of the Investigators, would compromise the ability to comply with the study requirements.
* History of cancer within the last 5 years, except basal cell carcinoma, non-squamous skin carcinoma, prostate cancer, or carcinoma in situ with no significant progression over the past 2 years.
* Significant orthopedic, cardiovascular, pulmonary, renal, liver, infectious disease, immune disorder, or metabolic/endocrine disorders or other disease that would preclude oral n-3 PUFA supplement ingestion and/or assessment of safety and study objectives
* Current illnesses which could interfere with the study (e.g. prolonged severe diarrhea, regurgitation, difficulty swallowing)
* Participation in a study of an investigational product less than 60 days or 5 half-lives of the investigational product, whichever is longer, before enrollment in this study
* Hypersensitivity to the test product
* Excessive alcohol consumption (\>21 units/week)
* Prior gastrointestinal b…