The RTS,S/AS01 malaria vaccine is being introduced sub-nationally in phased pilot introductions through the EPI programmes in Malawi Ghana and Kenya. Vaccine introduction is by the respective MoH in selected areas randomly assigned to receive the vaccine at the beginning of the pilots. In the context of this programmatic activity, the Malaria Vaccine Pilot Evaluation (MVPE) registered here as observational evaluations during early vaccine introduction, include a series of 3 household surveys, and sentinel hospital and community mortality surveillance, building on routine systems. These observational evaluations will measure: 1. The programmatic feasibility of delivering a 4 dose schedule; 2. Safety in routine use, with focus on cerebral malaria and meningitis; 3. The impact of the malaria vaccine in routine use on severe malaria and all-cause mortality
Age range
1 Month – 59 Months
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
The number of deaths of any cause
Timeframe: From 0 to 46 months after vaccination starts
Number of children admitted with a diagnosis of probable and confirmed meningitis cases
Timeframe: From 0 to 30 months after vaccination starts
Number of children admitted with a diagnosis of cerebral malaria
Timeframe: From 0 to 30 months after vaccination starts
Number of children aged 12-23 months who have completed the primary series (the 3 dose regime) of the malaria vaccine
Timeframe: At 18 months after vaccination starts
Number of children aged 27-38 months who have completed the 4th dose of the malaria vaccine
Timeframe: At 30 months after vaccination starts