This study evaluates two methods of aortic heart valve replacement in adults aged 18-60, the Ross procedure versus conventional aortic valve replacement using a biologic or mechanical heart valve. The Ross procedure replaces a patient's diseased aortic valve with his/her own pulmonary valve and uses a donor valve in the pulmonary position which receives less stress than the aortic valve. Mechanical valves tend to form blood clots so they need long-term blood thinners that increase risk of bleeding and lower quality of life. Animal tissue valves reduce clotting and bleeding risks but wear out sooner and shorten patient life-span.
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Full trial primary outcome - The rate of survival free of a composite of life-threatening valve-related complications (major bleeding, stroke or systemic thromboembolism, valve thrombosis, and operated-on valve reintervention)
Timeframe: Through trial completion, estimated to be 10 years
Measure the pilot trial capacity to enrol a mean of 6 patients per centre per year to determine the feasibility of a full trial
Timeframe: Through completion of the pilot trial, estimated to be 3 years
The rate of compliance with allocation in the pilot trial to determine the feasibility of a full trial
Timeframe: Through completion of the pilot trial, estimated to be 3 years
Measure the proportions of type of conventional valve used in the pilot trial
Timeframe: Through completion of the pilot trial, estimated to be 3 years