Linaclotide in Treating Patients With Stages 0-3 Colorectal Cancer

Inclusion Criteria: * History of 1 or more sporadic colorectal adenoma on previous endoscopy (adenoma cohort) or stage 0-3 biopsy proven colorectal cancer (CRC) (colorectal cancer cohort) who are scheduled for a surgical procedure * Ability to understand and willingness to sign a written informed consent document and follow study procedures * Ability to swallow capsules without difficulty * Ability to maintain pill diaries * Willingness to employ adequate contraception for men and women of childbearing potential for the duration of the study. Acceptable methods include double barrier methods, intrauterine device (IUD), postmenopausal status, and/or documentation of surgical sterilization * Participants must have no chronic, clinically severe health issues which, in the opinion of their physician or the research team, could preclude trial activities including the one week drug exposure phase Exclusion Criteria: * History of gastroparesis * History of celiac disease * Inflammatory bowel disease (Crohn's disease, ulcerative colitis) * Microscopic colitis, including collagenous colitis * Has taken linaclotide within 30 days prior to consent * Any malignancy except colorectal cancer or any active radiotherapy or cytotoxic chemotherapy within the last 6 months of baseline. Participants with a history of basal cell or squamous cell skin cancer may be enrolled at the discretion of the investigator * Participants may not be receiving any other investigational agents, or be active p…