PET Study in Multiple Sclerosis

Inclusion Criteria: * Subjects diagnosed with Multiple Sclerosis according to the 2010 McDonald criteria or otherwise in the opinion of the investigator (including relapsing-remitting and primary-progressive). * Aged 18 to 60 years. * Mixed affinity binder according to rs6971 TSPO polymorphism1. * Creatinine clearance over 60 mL/min\*). \* Blood result valid up to 3 months prior to the MRI scan. Exclusion Criteria: * Low and high affinity binders according to rs6971 TSPO polymorphism * Subject pregnant or breastfeeding. * Subjects with a Body Mass Index (BMI) \>35kg/m³. * Hospitalization within 1 month of screening visit. * Medical history or current heart failure * Medical history or current pulmonary failure * Current or Historical Drug or alcohol abuse in the opinion of the investigator. * Regular use of anti-inflammatory agents (more than once a week use of aspirin, NSAIDS, Steroids, immunomodulating drugs), unless patient is able to washout from anti-inflammatory drugs 2 weeks prior to PBR PET scan. * Neurological disorder other than MS, including Brain Trauma, stroke, Parkinson disease, Alzheimer disease, encephalitis. * Subjects with a history of radiation treatment or other high amounts of radiation exposure in the opinion of the investigator. * Subjects with a history of metastatic cancer including solid tumors and hematological malignancies, except basal cell, in situ squamous cell carcinoma of the skin, and in situ carcinoma of the cervix or the uterus that have…