UnknownPhase 3

TACE(Transcatheter Arterial Chemoembolization ) Associated With Systemic Chemotherapy Versus Systemic Chemotherapy Alone in Patients With Unresectable CRLM(Colorectal Liver Metastases)

China168 participantsStarted 2016-01

Plain-language summary

To date no randomized controlled trials have been completed that demonstrated whether TACE(Transarterial chemoembolization) is an effective adjunct to systemic chemotherapy (target therapy) with respect to advantages in conversion resection rates and survival compared with chemotherapy (target therapy) alone for patients who failed with first-line chemotherapy.The primary objective of this trial is to determine conversion resection rates and survival for patients with colorectal cancer liver metastasis are treated with TACE plus chemotherapy ± target therapy, compared to chemotherapy ± target therapy in the 2nd, and 3rd line.

Who can participate

Age range18 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients must have histologically confirmed CRLM * disease limited to the liver Unresectable disease by surgery or other local therapies * Age \> 18 years * Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2,child pugh A or B * Expected survival ≥ 3 months * Adequate hematological, hepatic and renal function * PD(progressive disease) after first line chemotherapy Exclusion Criteria: * pregnant or lactating women * patients with severe organ dysfunction or failure * with severe cardiovascular or mental disease

What they're measuring

Progression free survival

Timeframe: 6 months

Trial details

NCT IDNCT03783559

SponsorFudan University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-12

View on ClinicalTrials.gov More Colorectal Adenocarcinoma Metastatic to the Liver trials