Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis With or Without the Presence of Nasal Polyps

Inclusion criteria

• ✓5. have nasal candidiasis
• ✓6. history or current diagnosis of any form of glaucoma or ocular hypertension
• ✓7. history of intraocular pressure (IOP) elevation on any form of steroid therapy
• ✓8. history or current diagnosis of the presence (in either eye) of a cataract unless both natural intraocular lenses have been removed
• ✓9. history of immunodeficiency
• ✓0. any serious or unstable concurrent disease, psychiatric disorder, or any significant condition that, in the opinion of the investigator could confound the results of the study or could interfere with the subject's participation or compliance in the study
• ✓1. have a positive drug screen or a recent (within 1 year of Visit 1 \[Screening\]) history of drug or alcohol abuse, or dependence that, in the opinion of the investigator could interfere with the subject's participation or compliance in the study
• ✓2. have participated in an investigational drug clinical trial within 30 days of Visit 1 (Screening)