RecruitingPhase 4

Effects of Opioids and NSAIDs on Sympathetic Nervous System and Vascular Function

Switzerland90 participantsStarted 2019-01-01

Plain-language summary

Evaluation of the effect of different analgesic treatments (Tramadol, Paracetamol, Diclofenac) on sympathetic nerve activity, blood pressure, heart rate, heart rate, and vascular function in osteoarthritis patients and healthy subjects.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Patients ≥ 18 years of age, male or female, with a diagnosis of osteoarthritis or healthy subjects ≥ 18 years of age;
✓. Written informed consent;

Exclusion criteria

✕. History of hypersensitivity or allergy to any of the study drugs
✕. Acute coronary syndrome, stroke, transient ischemic attack, cardiac, carotid or other major CV surgery, percutaneous coronary intervention (PCI) or carotid angioplasty within the 3 months prior to Visit 1;
✕. Coronary or carotid artery disease likely to require surgical or percutaneous intervention within the 3 months after Visit 1;
✕. Presence of significant endocrine diseases;
✕. Presence of active acute infectious diseases;
✕. Known narrow-angle glaucoma;
✕. Known epilepsy;
✕. Cimino-shunt operation on both arms;

What they're measuring

resting MSNA (sympathetic nervous activity )

Timeframe: 1day (110 min)

changes in FMD (Flow mediated vasodilation)

Timeframe: 1 day (210min)

Trial details

NCT IDNCT03781544

SponsorUniversity of Zurich

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-07-31

Contact for this trial

Isabella Sudano, MD

+41442555841 Isabella.Sudano@usz.ch

View on ClinicalTrials.gov More Osteoarthritis of Multiple Joints of Ankle or Foot trials