Efficacy of Rapamycin (Sirolimus) in the Treatment of Peutz-Jeghers Syndrome

Inclusion Criteria: * Patients are diagnosed with PJS. * Patients have gastrointestinal polyps related syndromes, including abdominal pain, abdominal distension, gastrointestinal bleeding, etc, with imageological examination suggesting intestinal obstruction or intussusception; or whose symptoms recur after previous digestive endoscopic treatment and surgery; or who are inappropriate or unwilling to accept the above treatment again and wish to receive pharmacotherapy. * Conventional treatment didn't work well in patients combined with PJS-related tumors. * Physical condition (ECGO): 0\~3 * Organ function is good and biochemical indices meet the following conditions: * AST≤2.5×upper limit of normal value (ULN), * ALT≤2.5×upper limit of normal value (ULN), * Serum total bilirubin (TSB)≤1.5×upper limit of normal value (ULN), * Creatinine≤1.5×upper limit of normal value (ULN). * No other medications have been received for intestinal polyps within 3 months prior to the clinical trial. * Patients participate in the trial voluntarily and have signed the informed consent by the participant or his/her legal guardian. Exclusion Criteria: * Patients underwent a surgery within 2 weeks. * Patients may need emergency surgery in the near future. * Patients are allergic to any ingredient of rapamycin. * Patients suffer from a disease requiring immediate blood transfusion. * Patients suffer from any disease or condition that may impact implementation of the study or interpretation…