UnknownNot Applicable

Chemical Peels and Fractional Laser on IGF-1 Levels in Skin

United States20 participantsStarted 2019-12-01

Plain-language summary

The purpose of this study is to evaluate the impact of fractional laser versus chemical peels on IGF-1 levels in skin.

Who can participate

Age range

55 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male and female subjects \>55 years old * Fitzpatrick type I-II * Able to provide informed consent. * Cutaneous photodamage of 3 or above on the Larnier photodamage scale (see Appendix). Exclusion Criteria: * Prior laser or peel treatment in the area evaluated in the current study in the past year. * Currently taking immunosuppressant medications known to interfere wound healing or anti-inflammatory medications (such as NSAIDs, or steroids). * Subjects who have underlying diseases that could alter wound healing response (such as Diabetes). * Currently taking insulin. * History of substance abuse, mental dysfunction, or other factors limiting ability to cooperate with study. * History of abnormal scarring such as Keloids. * History of vitiligo. * Allergy or sensitivity or allergy to topical anesthesia * Inability to use sunscreen. * History of smoking in the last 10 years * Scar or prior surgery in the area of treatment. * Use of isotretinoin in the prior 6 months * Subjects who have bleeding disorders or who are taking anticoagulants

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

IGF-1 Levels

Timeframe: 3 months

Trial details

NCT IDNCT03775031

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-07-01

Contact for this trial

Molly Wanner, MD

617-726-5066 mwanner@mgh.harvard.edu

View on ClinicalTrials.gov More Skin Cancer trials

Who can participate

Age range

55 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.