Aim of this trial is to define if Post-Operative Cognitive Dysfunction, detected analyzing changes between pre-operative and post-operative Neurocognitive Test, and Postoperative Delirium, relate to concentration of effector's site concentration of propofol and remifentanil TCI and to the common intraoperative neuromonitoring values as well as to Pupillometry values (in particular Pupil Diameter, Pupil Latency, and Maximum Contraction Velcoity).
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Incidence of Post-Operative Cognitive Dysfunction in breast-surgery patients detected with Montreal Cognitive Assessment test
Timeframe: Patients will be subjected to Global Examination of Mental Test (GEMS) test one day before surgery and 1 day after surgery.
Incidence of Post-Operative Cognitive Dysfunction in breast-surgery patients detected with Trail Making Test A and B
Timeframe: Patients will be subjected to Trail Making Test (TMT) A and B one day before surgery and 1day after surgery.
Incidence of Post-Operative Delirium in breast-surgery patients
Timeframe: Patients will be subjected to Confusion Assessment Method (CAM) within 1 hour from awakening from anesthesia .
Incidence of Post-Operative Cognitive Dysfunction in breast-surgery patients
Timeframe: Patients will be subjected to Short Portable Mental Status Questionnaire one day before surgery and 1 day after surgery.
Incidence of Post-Operative Cognitive Dysfunction in breast-surgery patients detected with MiniMental State Evaluation test
Timeframe: Patients will be subjected to Confusion Assessment Method (CAM) within 1 hour from awakening from anesthesia.
Incidence of Emergence Delirium in breast-surgery patients detected with 4AT test
Timeframe: Patients will be subjected to 4 AT test within 1 day from awakening from anesthesia .