EUS-RFA for Unresectable Pancreatic Ductal Adenocarcinoma

Inclusion Criteria: * Patients in the age group 20 to 80 years * A cytological or histological diagnosis of inoperable PDAC based on multidisciplinary review of cross sectional imaging and cytology or histology results. * Patients who have been deemed unfit for surgical resection of the PDAC subjects who are fit for surgical resection but have declined surgery will also be considered for the study * PDAC patients presenting with jaundice to be considered after a successful biliary drainage * Patients ought to be fit enough to be considered for the study (ECOG performance status 0, 1 or 2) * Patients capable of giving informed consent Exclusion Criteria: * Inability to give informed consent * Pregnancy or breast feeding * ECOG performance status 3 or 4 * Life expectancy less than 3 months * Patients with distant metastases or malignant ascites