CompletedNot Applicable

Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO

Austria44 participantsStarted 2018-11-06

Plain-language summary

The acute respiratory distress syndrome (ARDS) is the most severe form of respiratory failure, presented in 10% of all intensive care patients and carrying a high mortality rate. Extracorporeal membrane oxygenation (ECMO) is a rescue treatment for patients with severe ARDS. Mechanical ventilator settings in patients with severe ARDS during ECMO therapy are not clearly defined at the moment.

Who can participate

Age range18 Years – 99 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Moderate to severe ARDS - Partial pressure of oxygen/Fraction of inspired oxygen (PaO2/FiO2) \< 200 mmHg * ECMO \< 24 hours in situ * Gender-matched * Age-matched Exclusion Criteria: * BMI \> 40 * Expected weaning of ECMO \< 3 days (postoperative ECMO) * Combustion * Restrictive chest wall impairment * Pregnancy

What they're measuring

Ventilator free days

Timeframe: Immediately after initiation of ECMO up to 28 days

Time from randomization to fulfillment of extubation criteria

Timeframe: Immediately after initiation of ECMO up to 28 days

Trial details

NCT IDNCT03764319

SponsorMedical University of Vienna

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-08-01

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