Daratumumab, Bortezomib, and Dexamethasone Followed by Daratumumab, Ixazomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma

Inclusion Criteria: * Participants must have histologically confirmed diagnosis of multiple myeloma * Participants must have measurable disease, as defined by at least one of the following: * Serum monoclonal protein M-protein level \>= 0.5 g/dL * Urinary M-protein excretion of \>= 200 mg over a 24-hour period * Involved free light chain level \>= 10 mg/dL, along with an abnormal free light chain ratio * Participants must have disease that has relapsed and/or refractory after their most recent therapy, with progressive disease (PD) being defined as an increase of 25% from the lowest response value in any one or more of the following: * Serum M-component protein (the absolute increase must be \>= 0.5 g/dL) and/or * Urine M-component protein (the absolute increase must be \>= 200 mg/24 hours) and/or * Only in participants without a measurable serum and urine M protein level: the difference between involved and uninvolved free light chain (FLC) levels (absolute increase) must be \> 10 mg/dL * Definite development of new bone lesions or soft tissue plasmacytomas or definite increase in the size of existing bone lesions or soft tissue plasmacytomas * Development of hypercalcemia (corrected serum calcium \> 11.5 mg/dL) that can be attributed solely to the plasma cell proliferative disorder * Participants with one to three lines of therapy for their disease with a prior therapy is defined as 2 or more cycles of therapy given as a treatment plan for multiple myelom…