In this trial the effects of the inhaled drug BAY1237592 will be studied in patients with high blood pressure in the pulmonary blood vessels due to Pulmonary Arterial Hypertension (PAH) and due to Chronic Thromboembolic Pulmonary Hypertension (CTEPH). Pulmonary hypertension is characterized by the elevation of pressure in the pulmonary arteries (PAP) and of the pulmonary vascular resistance (PVR) leading to increased workload of the right chamber of the heart to eject blood against this elevated resistance. The goal of this study is to measure the safety and tolerability of the drug as well as the reduction of the PVR at different doses In Part A patients without specific treatment for PH (untreated patients) will be tested. In Part B also patients stably pre-treated with specific PH drugs will be studied in combination with the new inhaled drug
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Peak percent reduction in PVR (Pulmonary vascular resistance) from "baseline 2" for untreated patients
Timeframe: Up to 5 hours post inhalation of BAY1237592 compared to "baseline 2"
Peak percent reduction in PVR from "baseline" for pre-treated patients
Timeframe: Up to 5 hours post inhalation of BAY1237592 compared to "baseline"