To observe and identify determinants of recovery from intensive care unit-acquired weakness (ICUAW) following a severe cardiorespiratory failure requiring extra-corporeal membrane oxygenation (ECMO). Additionally, to discover the effects of ICUAW on physical function and health-related quality of life (HRQoL) after critical illness. CLEVERER is a clinical observational pilot study.
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To observe the change in cross sectional area of the Rectus Femoris (RFcsa, measured in cm2) during critical illness and recovery.
Timeframe: Up to approximately 1 year.
To Observe a change in Hand Held Dynamometry strength and correlate this with RFcsa, function and HRQoL during critical illness and recovery.
Timeframe: Up to approximately 1 year.
To observe a change in Knee straightening dynamometry, strength and joint moment (torque) and correlate this with RFcsa, function and HRQoL during critical illness and recovery.
Timeframe: Up to approximately 1 year
To test the Medical Research Council Sum Score (MRC-SS). MRC-SS measures global strength and ambulation
Timeframe: Up to approximately 1 year.
To observe a change in Short Physical Performance Battery (SPPB) and correlate this with RFcsa, function and HRQoL during critical illness and recovery
Timeframe: Up to approximately 1 year.
Lying and Standing Vital Capacity (FVC - forced vital capacity) and correlate this with RFcsa, function and HRQoL during critical illness and recovery.
Timeframe: Up to approximately 1 year
To measure a change in Free Fat Mass Index (FFMI) and correlate this with RFcsa, function and HRQoL during critical illness and recovery.
Timeframe: Up to approximately 1 year
To measure the EQ-5D-5L (Euroscore) to assess general health and correlate this with the primary objective (RFcsa).
Timeframe: Up to approximately 1 year
Hospital anxiety and depression score (HADS) to assess HRQoL and correlate this with the overall primary objective (RFcsa).
Timeframe: Up to approximately 1 year
Reintegration to normal living index (RNLI) to assess HRQoL and correlate this with the overall primary objective (RFcsa).
Timeframe: Up to approximately 1 year
10-item questionnaire to assess HRQoL (pre-morbid functional status) and correlate this with the overall primary objective.
Timeframe: Day 0 (on admission)