Study of Efficacy of PEAR-004 in Schizophrenia

Key Inclusion Criteria: * Signed informed consent must be obtained prior to participation in the study. * Healthy male and female subjects 18 to 65 years of age, inclusive, and in good health as determined by medical history, physical examination, and vital signs at screening * SCID-based DSM-5 diagnosis of schizophrenia and a total PANSS score \> 60 * Proficient in English at 5th grade reading level or higher, in the judgement of the investigator * Capable of using a mobile device (compatible with PEAR-004) and using common applications, in the judgement of the investigator Key Exclusion Criteria: * Major change in primary antipsychotic medication in the prior 4 weeks before screening (e.g., switching to a new agent or a dose adjustment within two weeks of randomization) * Planning to move out of the geographic area within 3 months * Unable to use English to participate in the consent process, the interventions or assessments * Inability to comply with study procedures, due to severe medical conditions or otherwise * Meet DSM-5 diagnosis for a current episode of major depression, mania, or hypomania in the past month * Meet DSM-5 diagnosis for a current moderate or severe alcohol or cannabis use disorder in the past 2 months * Meet DSM-5 diagnosis for a current substance use disorder (other than alcohol or cannabis) in the past 2 months * Considered high risk for suicidal behavior based on ISST-Plus score at screening, or in the judgement of the investigator * Previously …