Whole Brain Radiation Therapy With Standard Temozolomide Chemo-Radiotherapy and Plerixafor in Treating Patients With Glioblastoma

Inclusion Criteria: * Patients must have tissue confirmation of high grade (World Health Organization (WHO) grade IV) glioma including but not limited to glioblastoma, gliosarcoma, glioblastoma with oligodendroglial features, glioblastoma with primitive neuroectodermal tumor (PNET) features. * The patient must have post-operative contrast enhanced imaging (computed tomography \[CT\] or magnetic resonance imaging \[MRI\]) unless only biopsy performed. For patients having biopsy alone, post-operative imaging is not routinely obtained and therefore the preoperative study will serve as baseline. * Patient should have surgery (biopsy, partial resection or gross total resection) and no additional anti-cancer therapy except the chemo-radiation as specified in the protocol. * Patients must have Karnofsky performance score \>= 60. * Absolute neutrophil count (ANC) \>= 1500 (at time of screening). * Platelets \>= 100,000 ml (at time of screening). * Serum creatinine =\< 1.5mg/dl (at time of screening). * Creatinine (Cr) clearance should be \> 50 mL/min (at time of screening). * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 3 times the upper limit of normal (at time of screening). * If female of childbearing potential, negative pregnancy test (at time of screening). * The patient or his/her legal representative must have the ability to understand and willingness to sign a written informed consent document. * Patient agrees to use an effective method of contrac…