UnknownNot Applicable

Immune Responses in Hen's Egg Oral Immunotherapy

50 participantsStarted 2014-03-18

Plain-language summary

The study determines how a 6 months oral immunotherapy (OIT) program with hen's egg (HE) effects cellular and humoral immune responses in 50 children with HE allergy. Clinical data, transcriptomics and epigenetics are combined and analyzed by advanced system biology methods. This study will provide better understanding of the effects and mechanisms of OIT.

Who can participate

Age range6 Years – 19 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age 6-19 years
✓. Sensitization to egg white (egg white- specific IgE ≥0.35 kU/l or skin prick test ≥3 mm)
✓. Positive double-blind, placebo-controlled food challenge to heated egg white

Exclusion criteria

✕. Poor adherence
✕. Uncontrolled or severe asthma
✕. Severe systemic illness
✕. Active autoimmune disease
✕. Active, malignant neoplasia

What they're measuring

OIT-induced allergen-specific antibody responses

Timeframe: Up to 32 weeks

OIT-induced changes in the peripheral blood cell transcriptome

Timeframe: Up to 32 weeks

OIT-induced allergen-specific expression profiles of messenger-RNAs and microRNAs

Timeframe: Up to 32 weeks

Trial details

NCT IDNCT03744325

SponsorHelsinki University Central Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-12-31

View on ClinicalTrials.gov More Food Allergy trials