Pulmonary Resectable Metastases of Osteosarcoma With Anti-angiogenics and CHemotherapy

Inclusion Criteria: * age between 10 and 50 years; * diagnosis of histologically confirmed high grade osteosarcoma; * identification of pulmonary metastases without the existence of local recurrence(previous re-resection of local recurrence with wide margin is allowed). * resectable pulmonary nodule(s), defined as nodule(s) that are removable by wedge resection/ segmentectomy/lobectomy without necessitating a pneumonectomy (e.g., nodules immediately adjacent to the main stem bronchus or main pulmonary vessels) * prior treatment consisted of standard National Comprehensive Cancer Network (NCCN) guideline recommended first-line chemotherapy * wide/radical-margin surgical resection of the primary tumor completed at least 4 weeks before enrollment. * Eastern Cooperative Oncology Group(ECOG) performance status 0-2 with a life expectancy \>3 months; * adequate renal, hepatic, and hemopoietic function; * normal or controlled blood pressure; * no thoracic comorbidities with adequate pulmonary function eligible for thoracic surgery Exclusion Criteria: * previously exposed to GD chemotherapy or VEGFR2 Tyrosine-kinase inhibitors (TKIs); * existence of local recurrence; * have had other kinds of malignant tumors at the same time; * cardiac insufficiency or arrhythmia; * uncontrolled complications, such as diabetes mellitus and so on; * coagulation disorders or Hemorrhagic diseases ; * metastases considered unresectable or borderline resectable at baseline * intolerable of thoracis sur…