Stopped: new study to be created
This phase I/IIa trial studies the side effects and best dose of a type of specialized immune cell (natural killer cell-like cytotoxic T-lymphocytes (CTLs) (nCTLs) and how well they work when given with a vaccine (alpha-type-1 polarized dendritic cells) in treating patients with stage II-IV ovarian, fallopian tube, or primary peritoneal cancer. nCTLs are immune cells that are isolated from each patient?s blood and "taught" in the laboratory how to recognize and eliminate tumor cells. These "educated" immune cells are then given back to the patient. An alpha-type-1 polarized dendritic cell vaccine is another population of "educated" immune cells that work to support the infused nCTLs. Giving nCTLS with a dendritic cell vaccine may work better in treating patients with ovarian, fallopian tube, or primary peritoneal cancer.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Incidence of adverse events as assessed by Cancer Therapy Evaluation Program (CTEP) version 4 of the Common Terminology Criteria for Adverse Events (CTCAE)
Timeframe: Up to 12 months
Dose-limiting toxicities (DLT) assessed by CTCAE version 5
Timeframe: Up to 14 days after intraperitoneal (IP) infusion of nCTLs
Change in immune response
Timeframe: From baseline (day 0) to day 2 (48 hours after adoptive cell therapy [ACT]) administration
Persistence of nCTLs after their adoptive transfer
Timeframe: Up to 4 weeks