Chemoembolization Using LifePearl Polyethylene Glycol Drug Eluting Microspheres With Doxorubicin in HCC

Inclusion Criteria: * Patients with confirmed diagnosis of HCC with CT scan, MRI or biopsy * Patient with un-resectable HCC and not indicated for other radical therapies, or waiting for transplant * Multinodular or single nodular tumor extended to \<50% of the liver * Hyper vascular lesion showing contrast enhancement in the early stage at the contrast media bolus injection CT or MRI. * At least one uni-dimensional lesion measurable according to the Modified RECIST criteria by CT-scan or MRI * No invasion in the blood vessel (hepatic portal, hepatic vein) or bile duct by the CT or MR * Eastern Cooperative Oncology Group performance status is 0 - 1 * Proper blood, liver, renal, heart function * Over 18 years old * Expected survival more than 6 months * Prior written patient consent Exclusion Criteria: * Extrahepatic metastasis (Any lymph nodes measuring ≥ 10mm along the short axis) * Tumor burden involving more than 50% of the liver * History of biliary tract repair or endoscopic biliary tract treatment * Clinically important refractory ascites or pleural fluid * Any contraindications for hepatic embolization procedures * Any contraindication for doxorubicin administration * Contrast media allergy contraindicating angiography * Acute or active cardiac, hepatic or renal diseases * Pregnant, nursing or childbearing age women and men who are sexually active and don't want to or can't do contraception