Allogeneic Regulatory Dendritic Cell (DCreg) Renal Study

Inclusion Criteria: Donor Eligibility Criteria: * Able to understand and provide informed consent; * Male or female \>/= 18 years of age * Meets all standard institutional criteria for kidney donation and Health Agency criteria for kidney donation; * For females of childbearing potential, a negative urine or serum pregnancy test; * Negative for Human Immunodeficiency Virus type 1 (HIV) -1 (antigen and Nucleic Acid Testing (NAT)), HIV-2, Human T-cell leukemia virus type 1 (HTLV-1), and HTLV-2; * Negative for hepatitis C (antibody and NAT), hepatitis B (surface antigen and core antibody), and Treponema pallidum infection; * Negative for West Nile Virus; * Negative health history for Creutzfeldt-Jakob disease; * No live vaccines within 8 weeks prior to leukapheresis; * No medical condition(s) that the investigator deems incompatible with participation in the trial; and * No use of investigational drugs within 12 weeks of participation. Recipient Inclusion Criteria: * Must be able to understand and provide informed consent; * Is \>/= 18 years old at the time of informed consent; * Is undergoing a living donor renal transplant; * For females of childbearing potential, a negative urine or serum pregnancy test upon study entry * The candidate agrees to use contraception with a method that is more than 80% effective (see FDA Office of Women's Health (http://www.fda.gov/birthcontrol). Female participants of child-bearing potential must consult with their physician and determine th…