Persistent cough is a distressing symptom for people with respiratory disorders. Patients also often experience an ongoing urge-to-cough that prompts coughing, and which fails to resolve the sensation. Understanding how the brain controls cough and the urge-to-cough could lead to new cough suppressing therapies. The overall objective of this project is to use functional brain imaging (fMRI) to identify brain regions that are involved in the exaggerated urge-to-cough in humans with chronic cough. Our focus will be on the brainstem where information from the airways first arrives in the central nervous system.
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Brainstem Neural Activations to Capsaicin
Timeframe: fMRI was performed in a single session on the day of the cough challenge testing session and not more than seven days after.
Brainstem Neural Activations to ATP
Timeframe: fMRI was performed in a single session on the day of the cough challenge testing session and not more than seven days after.