CompletedNot Applicable

Plasmodium and Other Parasites in Pregnant Women and Children Around Margibi and Montserrado Counties, Liberia

Liberia1,264 participantsStarted 2019-10-01

Plain-language summary

Background: The disease malaria affects many people in Liberia and other parts of Africa. It is caused by germs that are spread by mosquito bites. It may be mild but can be serious or can lead to death if not diagnosed and treated. Children younger than 5 years old and pregnant women are most at risk of malaria. Worms also infect many people in Liberia. They can be caused by mosquito bites or by touching soil or still water. Worm infections can be mild or serious. Doctors in Liberia and their NIH partners want to learn more about these diseases in women and children. Objective: To measure how much malaria and worm infections there are in pregnant women and children in two counties of Liberia. Eligibility: Pregnant women ages 18 and older and children ages 6 12 months seeking routine care at C.H. Rennie Hospital or the Duport Road Health Center Design: Participants will be screened with questions about their health or their child s health. Participants will be asked further questions about their health and about their home life. Participants will give a small amount of blood by finger prick. This will be tested to see if they have malaria or some types of worms, and for research studies. Participants who are sick from malaria will be treated at a study clinic. Treatment will follow standards of the Liberia and/or the World Health Organization.

Who can participate

Age range6 Months

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

* INCLUSION CRITERIA: * For pregnant women, a study participant must satisfy the following criteria to be enrolled in this study: * Pregnant woman \>=18 years of age reporting for routine care at the center without acute illness or abnormal vital signs (e.g.fever, SBP \> 160, OR DBP \> 110) per standard clinic procedures * The study participant understands the study and gives informed consent for participation * Willingness to share a positive test result for malaria or helminths with the C.H. Rennie Hospital or the Duport Road Health Center so treatment can be initiated if necessary * For children, a study participant must satisfy the following criteria to be enrolled in this study: * Children 6-12 months of age at time of visit presenting for routine care at the center without acute illness or abnormal vital signs (e.g. fever) per standard clinic procedures * The parent or guardian understands the study and gives informed consent for participation of their child * Willingness of parent/guardian to share a positive test result for malaria or helminths with the C.H. Rennie Hospital or the Duport Road Health Center so treatment can be initiated if necessary EXCLUSION CRITERIA: * For women, prior enrollment in the study during the same pregnancy * For children, prior enrollment in the study * Conditions that in the judgment of the Principal Investigator or Clinical Investigators could adversely impact the safety of the study participant, including conditions tha…

What they're measuring

Measurement of the frequency of P. falciparum parasitemia as defined by rapid diagnostic tests and/or blood smears

Timeframe: Seasonal and year of sample collection

Trial details

NCT IDNCT03719599

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)

Sponsor typeNIH

Study typeOBSERVATIONAL

Primary completion2021-02-04