Combination HTNV and PUUV DNA Vaccine

Inclusion Criteria: * Healthy adult male or nonpregnant, nonlactating female, ages 18-49 (inclusive) at time of screening * Have demonstrated adequate comprehension of the protocol by achieving a score of at least 80% correct on a short multiple-choice quiz. Individuals who fail to achieve a passing score on the initial quiz will be given the opportunity to retest after a review of the protocol information. Individuals who fail the quiz for the second time will not be enrolled. * Have provided written informed consent before screening * Subject is in good health as determined by past medical history, medication use, and abbreviated physical examination * Good health is defined by the absence of any medical condition described in the exclusion criteria in a subject with a normal abbreviated physical examination including vital signs. If the subject has another current, ongoing medical condition, the condition cannot meet any of the following criteria: (1) first diagnosed within 3 months of enrollment, (2) is worsening in terms of clinical outcome in last 6 months, or (3) involves need for medication that may pose a risk to subject's safety or impede assessment of adverse events or immunogenicity if they participate in the study. * An abbreviated physical examination differs from a complete physical examination in that it does not include a genitourinary and rectal examination. * Available and able to participate for all study visits and procedures * Sexually active men a…