Tacrolimus for Malar Edema

Inclusion Criteria: * Bilateral lower lid blepharoplasty, facelift, or both. * Patients over 18 years of age. Exclusion Criteria: * -Patients presenting for revision surgery. * Patients with a known allergy to tacrolimus. * Patients taking medications that alter tacrolimus metabolism: * Anticonvulsants: carbamazepine, phenobarbital, phenytoin * Antibiotics: rifampicin, rifabutin * Antifungal: clotrimazole, ketoconazole, fluconazole, itraconazole * Ca++ channel blockers: diltiazem, nifedipine, nicardipine, verapamil * Macrolides: erythromycin, clarithromycin, troleandomycin * Miscellaneous: cyclosporin A, danazol, bromocriptine, cimetidine, methylprednisolone, protease inhibitors * Patients with previously diagnosed reduced kidney function. * Immunocompromised patients. * Patients with a history of cutaneous facial malignancies. * Patients with active cutaneous facial infections.