CompletedNot Applicable

The Effects of Probiotics on Intestinal Permeability in Gastrointestinal Cancer Patients in Chemotherapy

Denmark5 participantsStarted 2018-07-01

Plain-language summary

The aim of this study is to test the hypothesis that adjuvant administration of probiotics in cancer patients undergoing chemotherapy can reduce a chemo-induced increased intestinal permeability. Furthermore, we hypothesize that the use of probiotics may reduce the occurrence of gastrointestinal side effects such as diarrhea, abdominal pains, bacterial translocation and infections following chemotherapy.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * GI cancer (all types) patients undergoing chemotherapy in oncologic department at Rigshospitalet in Copenhagen * Age \>18 years * Patients with at least three planned chemo therapy sessions left Exclusion Criteria: * Pregnant * Patients who don't speak, write or understand Danish * Known inflammatory bowel diseases or malabsorption * Chronic kidney disease (2 x upper limit plasma creatinine) * Neutropenia (\< 1.5 x 109/L neutrophilic granulocytes in peripheral blood) * Use of antibiotics * Use of lactulose (laxative) and not able to discontinue three days prior to urin collection (lactulose/mannitol test) * Use of probiotics

What they're measuring

Intestinal permeability

Timeframe: 4 hours

Trial details

NCT IDNCT03704727

SponsorUniversity of Copenhagen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-02-01

View on ClinicalTrials.gov More Intestinal Permeability trials