Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5%

Inclusion Criteria: * Male or female cirrhotic subjects between 18 and 79 years of age. * Subjects with ACLF-1b, ACLF-2, or ACLF-3a detected either at admission or during hospitalization (must be ACLF-1b, -2, or -3a within the Screening Period \[a maximum of 10 days\]). * Willing and able to provide written informed consent or have an authorized representative able to provide written informed consent on behalf of the subject in accordance with local law and institutional policy. * In case of HE, informed consent will be provided by a relative or a legally authorized representative if the subject is considered incompetent to consent. Exclusion Criteria: * Subjects without ACLF. * Subjects with ACLF-1a or ACLF-3b after the Screening Period. * Subjects fulfilling inclusion criteria that improve to no ACLF or to ACLF-1a or worsen to ACLF-3b during the Screening Period (between initial evaluation and time of randomization). * Subjects with ACLF for more than 10 days prior to randomization. * Subjects with acute or subacute liver failure without underlying cirrhosis. * Subjects with septic shock requiring use of norepinephrine (\> 0.3 mcg/kg/min) or need for a second vasopressor (including terlipressin). * Subjects with active bacterial or fungal infection: who have received less than 24h of appropriate antibiotic treatment. * Subjects with severe respiratory failure with PaO2/FiO2 ≤200. * Subjects with active or recent bleeding (unless controlled for \>48 hours). * Subjects wit…