RecruitingNot Applicable

ECoG BMI for Motor and Speech Control

United States3 participantsStarted 2018-11-09

Plain-language summary

Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.

Who can participate

Age range21 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age \> 21
✓. Limited ability to use upper limbs, based on neurological examination, due to stroke, amyotrophic lateral sclerosis (ALS), multiple sclerosis, cervical spinal cord injury, brainstem stroke, muscular dystrophy, myopathy or severe neuropathy.
✓. Disability, defined by a 4 or greater score on the Modified Rankin Scale, must be severe enough to cause loss of independence and inability to perform activities of daily living.
✓. If stroke or spinal cord injury, at least 1 year has passed since onset of symptoms
✓. Must live within a two-hour drive of UCSF

Exclusion criteria

✕. Pregnancy or breastfeeding
✕. Inability to understand and/or read English
✕. Inability to give consent
✕. Dementia, based on history, physical exam, and MMSE
✕. Active depression (BDI \> 20) or other psychiatric illness (active general anxiety disorder, schizophrenia, bipolar disorder, obsessive-compulsive disorder (OCD), or personality disorders (e.g. multiple personality disorder, borderline personality disorder, etc.)
✕. History of suicide attempt or suicidal ideation
✕. History of substance abuse
✕. Co-morbidities including ongoing anticoagulation, uncontrolled hypertension, cancer, or major organ system failure

What they're measuring

Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]

Timeframe: Up to 6 years post-implant period

NIDCD Primary Objective 1

Timeframe: Up to 6 years post-implant period

NIDCD Primary Objective 2

Timeframe: Up to 6 years post-implant period

Trial details

NCT IDNCT03698149

SponsorKarunesh Ganguly

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2030-08-15

Contact for this trial

Adelyn Tu-Chan

(415) 575-0431 adelyn.tu@ucsf.edu

View on ClinicalTrials.gov More ALS trials

Who can participate

Age range21 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age \> 21
✓. Limited ability to use upper limbs, based on neurological examination, due to stroke, amyotrophic lateral sclerosis (ALS), multiple sclerosis, cervical spinal cord injury, brainstem stroke, muscular dystrophy, myopathy or severe neuropathy.
✓. Disability, defined by a 4 or greater score on the Modified Rankin Scale, must be severe enough to cause loss of independence and inability to perform activities of daily living.
✓. If stroke or spinal cord injury, at least 1 year has passed since onset of symptoms
✓. Must live within a two-hour drive of UCSF

Exclusion criteria

✕. Pregnancy or breastfeeding
✕. Inability to understand and/or read English
✕. Inability to give consent
✕. Dementia, based on history, physical exam, and MMSE
✕. Active depression (BDI \> 20) or other psychiatric illness (active general anxiety disorder, schizophrenia, bipolar disorder, obsessive-compulsive disorder (OCD), or personality disorders (e.g. multiple personality disorder, borderline personality disorder, etc.)
✕. History of suicide attempt or suicidal ideation
✕. History of substance abuse
✕. Co-morbidities including ongoing anticoagulation, uncontrolled hypertension, cancer, or major organ system failure