Characterization of Retinal Vascular Disease in Eyes With Mild to Moderate NPDR in Diabetes Type 2

* Informed consent. * Diabetes Mellitus type 2 according to 1985 WHO criteria. * Age between 35 and 85 years. At least in one eye: Mild or moderate DR, with NPDR levels 20, 35, 43 and 47 (based on the ETDRS criteria - 7 fields CFP); * Absence of CIME or PDR; * Presence of at least 1 MA in the central 6000 µm in diameter area - Field 2; * No previous intravitreal injections; * BCVA 75 letters (20 /32); * Refraction with a spherical equivalent less than 5 Dp. At 6 months (Visit 2), at least one of the following criteria should be met: Phenotype B criteria: \- OCT RT above the following thresholds (DRCR.net criteria)(16,29) For ETDRS levels 20, 35, 43 and 47 at least 1 of the following criteria should be met at month 6: Central RT (within centre circle 1000 µm in diameter area) above abnormal gender-specific thickness assessed based on OCT (DRCR.net criteria). Defined, considering Cirrus SD-OCT, the following thresholds (2): * Central RT between 260 and 290 µm for women (SCME) and between 275 and 305 µm for men (SCME) * Central RT greater than 290 µm for women (CIME) and Central RT greater than 305 µm for men (CIME). OR Phenotype C criteria: \- MA Turnover ≥ 6, assessed by RetmarkerDR. OR Patients who do not meet the eligibility criteria in visit 2 for phenotype B or C but that were previously identified as phenotype B or C will also be considered as eligible by investigator decision. Exclusion Criteria * Cataract or other eye disease that may interfere with fundus…