Phase 2 Herniorrhaphy Study for Opioid Elimination

Inclusion Criteria: * Is scheduled to undergo a unilateral open inguinal herniorrhaphy with mesh under general anesthesia. * Has an American Society of Anesthesiologists Physical Status of I, II, or III. * Female subjects are eligible only if not pregnant, not lactating, not planning to become pregnant during the study, sterile; or using acceptable contraceptives. Exclusion Criteria: * Had any prior inguinal hernia repair except as a child (less than 6 years of age). * Has a planned concurrent surgical procedure (eg, bilateral herniorrhaphy). * Has a pre-existing concurrent acute or chronic painful physical/restrictive condition expected to require analgesic treatment in the postoperative period for pain. * Has a contraindication or a known or suspected history of hypersensitivity or clinically significant idiosyncratic reaction to required study medications. * Has known or suspected daily use of opioids for 7 or more consecutive days within the previous 6 months. * Has taken any NSAIDs within least 10 days prior to the scheduled surgery. * Has taken long-acting opioids within 3 days prior to the scheduled surgery. * Has taken any opioids within 24 hours prior to the scheduled surgery. * Has been administered bupivacaine within 5 days prior to the scheduled surgery. * Has been administered any local anesthetic within 72 hours prior to the scheduled surgery. * Has initiated treatment with study medications within 1 month prior to study drug administration that can impact pa…