Oral Tramadol Versus Oral Celecoxib for Post-perineal Repair Analgesia (NCT03694873) | Clinical Trial Compass
UnknownPhase 4
Oral Tramadol Versus Oral Celecoxib for Post-perineal Repair Analgesia
200 participantsStarted 2018-10-10
Plain-language summary
This trial will be performed to compare the effectiveness of oral tramadol versus oral celecoxib for the management of perineal pain following episiotomy or perineal tear repair after spontaneous vaginal birth in obese women
Who can participate
Age range18 Years – 35 Years
SexFEMALE
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Inclusion Criteria:
* Age:18-35 years
* Obese women with BMI ≥ 30.
* completed full 37-weeks gestation.
* spontaneous vaginal delivery with medio-lateral episiotomy or perineal tear requiring repair.
* Singleton alive fetus.
Exclusion Criteria:
* known allergy to investigated drugs(tramadol or celecoxib).
* regular use of analgesic drugs before or during pregnancy.
* any medical condition known to be potentially exacerbated by opioids, including alimentary canal disorders, hepatic and renal disease.
* instrumental vaginal delivery.
* 3rd or 4th degree perineal tear.
* severe postpartum haemorrhage (\>1,500 ml).
* complicating maternal diseases (pregestational/gestational diabetes mellitus; bleeding disorders; pre-eclampsia and other hypertensive disorders of pregnancy).
* epidural nor combined spinal-epidural analgesia in labour
* a history of peptic ulcer,asthma,thrombocytopaenia.