Mindfulness - Based Intervention in the Treatment of Fatigue in Patients With Primary Biliary Cholangitis

Inclusion Criteria: * Primary Biliary Cholangitis as defined by previously published criteria * On stable therapy with UDCA for at least 6 months before enrollment * Primary Biliary Cholangitis-40 fatigue domain score \> 33 * The ability to provide written consent Exclusion Criteria: * A known medical condition or metabolic disorder sufficient to explain fatigue such as anemia, thyroid disease, renal failure, use of beta-blockers and untreated depression * Active drug or alcohol use or history of drug and/or stimulant abuse * History of psychosis * Modification of treatment for underlying PBC in the preceding six months * Other serious coexistent conditions such as pre-existing advanced malignancy or severe cardiopulmonary disease which would be expected to limit their life expectancy * Anticipated need for transplantation in one year (Mayo survival model \<80% one-year survival without transplant) or MELD above 15 * Recurrent variceal bleeding, presence of diuretic-resistant ascites, or spontaneous encephalopathy * Non-proficiency in English