FUDR/Oxaliplatin HAI Plus Irinotecan vs. FOLFOXIRI Chemotherapy in Treating Initially Unresectable CRCLM

Inclusion Criteria: * Age ≥ 18 and ≤70. * Diagnosed as colorectal adenocarcinoma by histology. * Confirmed as liver metastases by medical imaging or pathology. * MDT determined as unresectable liver metastases, defined as:①more than 5 metastases; ②unable to conduct R0 resection; ③no sufficient residual liver volume after resection; ④none of 3 hepatic vein can be reserved after resection, no sufficient blood supply or bibliary duct can be reserved, none of 2 adjacent liver segment can be reserved. Whenever meets any of the criteria mentioned above would be defined as unresectable liver metastases. * No previous treatment aiming at treating liver metastases, including chemotherapy, surgery, radiotherapy, transcatheter hepatic arterial chemoembolization(TACE) or target therapy. * Confirmed by CT, MRI or PET/CT(if necessary) that there is no extrahepatic metastases or only oligos extrahepatic metastases(no more than 2 organs and 5 leisions, maximum diameters of single leision ≤ 1cm). * Unsuitable for cetuximab treatment(RAS mutation, unable to afford the cost). * No hematologic dysfunction(Platelets \>90×10\^9/L; WBC \>3×10\^9/L; Neutrophil \>1.5×109/L). * Serum bilirubin ≤ 1.5 × ULN; aminotransferase ≤ 5 × ULN. * No ascites; no coagulation dysfunction; albumin ≥ 30g/L. * Hepatic function was classified as class A by Child-Pugh classification. * Serum creatinine \< 1 × ULN, or creatinine clearance rate(CCR) \> 50ml/min(calculated by Cockcroft-Gault formula). * ECOG scored as 0-1…