Alleviation by Fisetin of Frailty, Inflammation, and Related Measures in Older Adults

Inclusion Criteria • Age ≥ 70 years Exclusion Criteria * Unable or unwilling to give informed consent * Pregnant * Body weight \>150 kg or body mass index (BMI) \> 50 * QTc\>450 msec * Total bilirubin \>2X upper limit of normal * Inability to tolerate oral medication * Abnormality in any of the screening laboratory studies (see below) * Human immunodeficiency virus infection * Known active hepatitis B or C infection * Invasive fungal or viral infection * Known hypersensitivity or allergy to fisetin * Uncontrolled pleural/pericardial effusions or ascites * New/active invasive cancer except non-melanoma skin cancers * Subjects taking medications that are sensitive to substrates or substrates with a narrow therapeutic range for CYP3A4, CYP2C8, CYP2C9, or CYP2D6 or strong inhibitors or inducers of CYP3A4 (e.g. cyclosporine, tacrolimus or sirolimus). If antifungals are absolutely necessary from an infectious disease perspective, then they will be allowed only if the levels are therapeutic. * Strong inhibitors of CYP3A4. See Appendices 1-3. * Tyrosine kinase inhibitor therapy * Known hypersensitivity or allergy to fisetin * Subjects on quinolone antibiotic therapy for treatment or for prevention of infections within 10 days. * Subjects taking H2-antagonists and unwilling to discontinue therapy for 1 week before and 2 weeks following enrollment. * Subjects taking potentially senolytic agents within the last year: Fisetin, Quercetin, Luteolin, Dasatinib, Piperlongumine, or Navitoc…