This crossover randomized controlled trial will evaluate the effects of purified gluten and whole wheat (gluten combined with amylase-trypsin inhibitors (ATIs)) on inducing intestinal and extra-intestinal symptoms in irritable bowel syndrome (IBS) patients. All participants will be put on a gluten-free diet and then challenged with muesli bars containing either purified gluten, whole wheat (gluten with ATIs), or gluten-free sham.
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Number of Participants With Worsening Irritable Bowel Syndrome (IBS) Symptoms Based on IBS-SSS
Timeframe: 1 week purified gluten or whole wheat (gluten+ATIs) intervention versus gluten-free sham. Outcomes were measured at baseline for Pre-Sham, Pre-Gluten and Pre-Wheat Arm/Groups and 1 week for Sham, Gluten and Wheat Arm/Groups.