The MOCA I Study - Microvascular Obstruction with CoFI™ System Assessment

Major Inclusion Criteria: * Patients 18 years of age or older presenting with ST-elevation myocardial infarction in the left anterior descending artery (LAD) undergoing primary percutaneous coronary intervention. * Competent mental condition to provide signed and dated ethics committee approved study consent prior to study related procedures * Eligible for prasugrel, ticagrelor, cangrelor, tirofiban, UFH and GP IIb/IIIa inhibitors * Referred for primary PCI within 5 hours of symptom onset with evidence of continuing ischemia and symptom to balloon time not exceeding 6 hours Major Exclusion Criteria: * Unconsciousness * Previous bypass graft surgery * Contraindication to CMRI * Recent or current major bleeding within 30 days prior to intervention * Recent major surgery within 30 days prior to intervention * End-stage heart failure with inotrope support and/or consideration for LVAD or heart transplant * Transient ischemic attack or stroke within 30 days prior to intervention * Pregnant or females of childbearing potential