This study is specifically designed to provide observational data which can be used to help in the design of future randomized clinical trials on both therapeutics and diagnostics for MDRO infections. To this end, clinical and epidemiological data will be collected on patients who have MDRO isolated from clinical cultures during hospitalization, as well as descriptions of the outcomes of patients treated with various antimicrobial regimens. Molecular and microbiological characterization will also be performed on MDRO isolates. These data will include a detailed clinical and epidemiological description of patients including identifying potential barriers to enrollment in future trials. In addition, data will be collected on species, strain type, and mechanism of drug resistance of the causative organism. Knowing the molecular characteristics will further inform future trial design as not all diagnostics detect and not all therapeutics are active against the same mechanisms of resistance.
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Disposition at Discharge
Timeframe: Up to 1 year from index culture date
Charlson Score
Timeframe: At 90 days after discharge from the index hospitalization
Pitt Bacteremia Score
Timeframe: On the day of index culture
Source of positive culture
Timeframe: At collection of the MDRO isolates
Length of Stay
Timeframe: Up to 1 year from index culture date
ICU Admissions
Timeframe: Up to 1 year from index culture date
Antibiotic Summary
Timeframe: Only during hospitalization and up to one year from index culture date
Survival Status
Timeframe: 90 days from discharge or up to one year from index hospitalization.
Readmission Status
Timeframe: 90 days after discharge from index hospitalization.