Cytokine Profile of Allergic Bronchopulmonary Aspergillosis
China100 participantsStarted 2014-12
Plain-language summary
The main aim of this study is to determine whether the levels of different inflammatory cytokines in the serum and BALF (bronchoalveolar lavage fluid) are relative to the severity and exacerbations of ABPA (allergic bronchopulmonary aspergillosis).
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
For ABPA patients
Inclusion Criteria:
* Patients diagnosed as allergic bronchopulmonary aspergillosis (ABPA). The diagnosis criteria of ABPA is as following: clinical diagnosis of asthma, elevated total IgE levels (\> 1,000 IU/mL), presence of specific IgE against A fumigatus detected (\> 0.35 kUA/L) or type 1 skin reaction to Aspergillus antigen. Other criteria(at least two of three): Presence of serum IgG antibodies (precipitins) against A. fumigatus; Radiographic pulmonary opacities consistent with ABPA(It might be transient consolidation, nodules, finger-in-glove opacities. Or it could be permanent bronchiectasis and pleuropulmonary fibrosis) Patients who sighed consent forms.
For asthma patients:
Diagnosis according to GINA.
For healthy control:
People with ongoing chronic allergic disease such as allergic rhinitis, asthma and allergic dermatitis are excluded.
Exclusion Criteria:
* Patients who are unwilling to sign the consent form.
What they're measuring
1
Cytokines levels
Timeframe: 1 year
Trial details
NCT IDNCT03643185
SponsorShanghai Pulmonary Hospital, Shanghai, China