Energy Expenditure From ECAL Indirect Calorimeter in a Multicomponent Weight Management Service

Inclusion Criteria: * BMI \> or equivalent to 30 kg/m2 to - 60 kg/m2 * Stable weight (change of \<5% within 12 weeks before screening based on medical history) * Subjects are well-motivated, capable and willing to learn how to undergo indirect calorimetry testing * Willing and able to adhere to prohibitions and restrictions specified within this protocol For Subjects participating in the glycaemic variability sub-study: * Subject understands instructions on the use of continuous glucose monitor sensor and is willing to undergo appropriate training and testing Exclusion Criteria: * Taking weight loss medication within 12 weeks prior to randomisation * Previous or planned bariatric surgery * History of Type 1, Type 2 diabetes mellitus, DKA or diabetes secondary to pancreatitis * Has HbA1c \> or equal to 6.5% or Fasting Plasma Glucose \> or equal to 7.0 mmol/L at screening. NOTE: a one-time repeat measurement is allowed, if value of HbA1c and/or FPG is not consistent with prior values * History of obesity with a known secondary cause (Cushing's disease/syndrome) * Oral corticosteroid use (except in the short term use of a 7-10 day course) * Ongoing, inadequately controlled thyroid disorder defined as thyroid-stimulating hormone \> 6 mIU/litre or \< 0.4 mIU/litre * History of malignancy within 3 years before screening (or diagnosis of malignancy within this period) * estimated glomerular filtration rate \< 30 ml/min/1.73m2 on serum testing * Alanine aminotransferase level …