Stopped: The study was stopped earlier than planned due to safety concerns about high levels of calcium in the blood of the participants
To evaluate long-term safety of denosumab in children/young adults with pediatric osteogenesis imperfecta (OI) who completed the prior study 20130173 (NCT02352753).
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Number of Participants With Adverse Events, Serious Adverse Events, and Adverse Events of Special Interest
Timeframe: From enrollment to end of study, including 24 weeks after last dose of denosumab for participants who received denosumab; the maximum time on study was 24 months.
Number of Participants With Anti-denosumab Antibodies
Timeframe: From enrollment to end of study, including 24 weeks after last dose of denosumab for participants who received denosumab; the maximum time on study was 24 months
Number of Participants With Clinical Laboratory Toxicities Grade ≥ 3
Timeframe: From enrollment to end of study, including 24 weeks after last dose of denosumab for participants who received denosumab; the maximum time on study was 24 months
Number of Participants With Clinically Significant Vital Sign Findings
Timeframe: From enrollment to end of study, including 24 weeks after last dose of denosumab for participants who received denosumab; the maximum time on study was 24 months
Number of Participants With Metaphyseal Index Z-score Above Age-appropriate Normal Range
Timeframe: Baseline, month 12 and month 24
Number of Participants With Abnormal Molar Eruption of the First or Second Molar Based on Radiological Findings
Timeframe: Baseline, month 12, and month 24
Percent Change From Baseline in Mandibular Shaping Parameters
Timeframe: Baseline and month 12 and month 24