A Study to Evaluate Ketamine for the Treatment of Rett Syndrome

Inclusion Criteria: * Female Rett Syndrome patients diagnosed with Rett Syndrome with a confirmed MECP2 mutation * between the ages of 6 and 12, inclusive, who have not achieved menarche * ability to take oral medications * are generally healthy. Exclusion Criteria: * Patients not on stable medication regimens/other types of behavioral, educational, or dietary interventions for at least 4 weeks, * are taking medications that may interact with ketamine, * have a condition where increased blood pressure, spinal fluid pressure, or ocular pressure may put the patient at increased risk.