Validation of Multimodal Evoked Potentials (mmEP) for Predicting Disease Progression in Multiple Sclerosis

Inclusion Criteria: * diagnosed with a clinically isolated syndrome (CIS) or MS with a relapsing-remitting (RRMS) or a primary progressive disease course (PPMS): * CIS: EDSS \<= 5.5 within six months of first clinical event * early RRMS: EDSS: \<= 3.5 disease course of 5 up to 10 years * late RRMS: EDSS: 2.0-5.5 inclusive disease course of 5 to 15 years * PPMS: EDSS: 2.0-6.5 inclusive disease course up to 15 years * participation in the Swiss Multiple Sclerosis Cohort Study (SMSC) * mental ability to cooperate * written informed consent Exclusion Criteria: * alcohol or substance abuse * progressive disease other than Multiple Sclerosis * psychiatric disorder requiring a treatment by a psychiatrist * patients with movable metal implants, e.g. pace-maker, stents, deep brain stimulators etc.;(patients with jaw- or bone-fixed metal implants can be included)