CompletedNot Applicable

Pharmacokinetic Study of Paracetamol in Patients Over 80 Years Hospitalized to an Acute Geriatric Ward

Belgium36 participantsStarted 2015-11

Plain-language summary

The goal of this exploratory study is the characterization of the pharmacokinetic (PK) profile of paracetamol in older patients and the specific PK (pharmacokinetic) variables associated with plasma exposure in this population.

Who can participate

Age range80 Years

SexALL

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Inclusion Criteria: * a minimum age of 80 years * admission to the acute geriatrics ward * oral intake of paracetamol 1000 milligram (mg) in tablet form tid * a steady state situation (defined as at least 4 consecutive intakes of paracetamol before sampling) Exclusion Criteria: * palliative care setting with downgrading of care

What they're measuring

Identification of the pharmacokinetic parameters: AUC

Timeframe: 8 hours (= during 1 dosing interval at steady state)

Identification of the pharmacokinetic parameters: Cmax

Timeframe: 8 hours (= during 1 dosing interval at steady state)

Identification of the pharmacokinetic parameters: Tmax

Timeframe: 8 hours (= during 1 dosing interval at steady state)

Trial details

NCT IDNCT03617471

SponsorUniversitaire Ziekenhuizen KU Leuven

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-01

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