Fecal Microbiota Transplantation for C. Difficile Infection in Solid Organ Transplant Recipients

Inclusion Criteria: * Is willing to provide written informed consent. * Is willing to comply with all study procedures and be available for the duration of the study. * Can take oral medication * At least 18 years of age. * Is a solid organ transplant (SOT) recipient * Has had at recurrent C. difficile infection defined as: positive C. difficile testing in stool and diarrhea (three or more loose stools over 24 hours) during the 180 day period following completion of treatment for prior episode * History of positive IgG test to cytomegalovirus (CMV) and Epstein-Barr Virus (EBV) for subject or donor * Clinical response to 4-14 days of oral antibiotic standard of care treatment for the current episode of CDI. Clinical response is defined as greater than or equal to 25% reduction of diarrhea. * Negative urine or serum pregnancy test for women of childbearing potential and agree to use effective form of contraception until 6 weeks post treatment Exclusion Criteria: * Major bowel resection surgery within 90 days of randomization * Active intestinal disease (e.g. Crohn's disease, ulcerative colitis) * History of total colectomy or bariatric surgery * Known or suspected toxic megacolon and/or small bowel ileus * Presence of colostomy or ileostomy. * Taking concomitant antibiotics within 48 hours of Visit 2. Topical antibiotics, and antibiotics for transplant prophylaxis are permitted * Dysphagia; oropharyngeal, S), or patient has evidence of dysphagia when the 'safety test' capsul…