CompletedPhase 2/3

Piroxicam and Levonorgestrel Co-treatment for Emergency Contraception

Hong Kong860 participantsStarted 2018-08-20

Plain-language summary

This is a randomised controlled trial aimed at comparing the efficacy of levonorgestrel (LNG) co-administered with piroxicam or placebo for oral emergency contraception (EC). Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) commonly used as a pain-killer in inflammatory conditions. Efficacy will be measured as the percentage of pregnancies prevented.

Who can participate

Age range

18 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * healthy women aged 18 years or above; * requesting emergency contraception within 72 h of a single act of unprotected intercourse in the current menstrual cycle; * having menstrual cycles between 24 and 42 days * willing to abstain from further acts of unprotected intercourse and; * available for follow-up over the next 6 weeks. Exclusion Criteria: * post-abortion or postpartum and period have not yet returned, * being on prescription drugs currently * having unprotected intercourse in this cycle more than 72 hours or more than once before attending the clinic, * being found pregnant at the time of presentation, * breastfeeding, * having been sterilized (or partner having been sterilized) or having intrauterine contraceptive device in-situ, * uncertain about the date of the last menstrual period, * having used hormonal contraceptive (including EC pill) or NSAID in the current or past one cycle, * having history of asthma, urticarial or other allergic reactions to piroxicam, aspirin or other NSAIDs, * having history of ischaemic heart disease in the past one year * having history of pelvic ulcer disease and/or gastrointestinal bleeding

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Percentage of Pregnancies Prevented

Timeframe: 1 month

Trial details

NCT IDNCT03614494

SponsorDr. Hang Wun Raymond Li

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-10-05

Results submitted2023-01-07

View on ClinicalTrials.gov More Emergency Contraception trials