CompletedNot Applicable

Genetic and Epigenetic Mechanisms of Developing Gestational Diabetes Mellitus and Its Effects on the Fetus

Russia850 participantsStarted 2015-08

Plain-language summary

This is a randomized controlled trial of different glycemic targets during tratment of women with GDM with assessement of epygenetic aspects of their effects on the fetus and pregnancy outcomes. This study is interventional, randomised controlled trial, open-label.

Who can participate

SexFEMALE

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Inclusion Criteria: * Pregnant women with GDM diagnosed according to the Russian national consensus and the recommendations of the International Association of Diabetes and Pregnancy Study Groups (fasting glucose of ≥5.1 mmol/L, and/or ≥10.0 mmol/L after 1 h, and/or ≥8.5 mmol/L after 2 h in oral glucose tolerance test (OGTT) with 75 g of glucose). * Gestational age at the time of inclusion in the study 12 weeks 0 days - 31 weeks 6 days * For control group: pregnant women with normal glucose tolerance confirmed by OGTT at 24-31 weeks of gestation. Exclusion Criteria: * Diabetes mellitus type 1 and tipe 2 * Other deseases that affect methabolism of carbohydrates * Use of drugs that affect methabolism of carbohydrates * Malformations of the fetus identifired prior to inclusion to the study.