Understanding Hypoglycaemia After Bariatric Surgery (NCT03609632) | Clinical Trial Compass
CompletedNot Applicable
Understanding Hypoglycaemia After Bariatric Surgery
Switzerland16 participantsStarted 2018-09-20
Plain-language summary
Postprandial hyperinsulinaemic hypoglycaemia is an increasingly recognized adverse side effect of bariatric surgery. Affected individuals experience low glucose levels 1-3 hours after intake of meals, accompanied by symptoms such as drowsiness, sweating, hunger and palpitations. Hypoglycaemia can be serious and have potential dangerous health impact (e.g. road accident or fall due to loss of consciousness). The pathophysiology is incompletely understood and more research is needed in search of preventive and therapeutic strategies.
Who can participate
Age range18 Years – 65 Years
SexALL
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Inclusion Criteria:
* Gastric bypass (RYGB) surgery performed ≥ 6 months ago
* Confirmed postprandial hypoglycaemia (continuous glucose monitoring or plasma glucose), with at least 2 episodes of Whipple's triad (symptoms, capillary of interstitial glucose ≤3.1mmol/L, symptom resolution by carbohydrate intake) ≤3 months ago
* Normal glucose control at recruitment and absence of (pre)diabetes before bariatric surgery
* Capacity to give informed consent
Exclusion Criteria:
* Fasting hypoglycaemia suggesting hyperinsulinism of different aetiology
* Use of medication that influence glucose metabolism
* Bariatric procedures other than RYGB
* Physical or psychological disease likely to interfere with the normal conduct of the study and interpretation of the study results as judged by the investigator
* Moderate to severe chronic kidney disease
* Pregnancy or breastfeeding
What they're measuring
1
Fractional synthesis rate of de novo C-peptide synthesis (%/hr)