This phase I/II trial studies the side effects and best dose of nivolumab when given together with multi-fraction stereotactic radiosurgery and to see how well they work with or without ipilimumab in treating patients with grade II-III meningioma that has come back (recurrent). Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue. Giving nivolumab and multi-fraction stereotactic radiosurgery with or without ipilimumab may work better in treating patients with grade II-III meningioma.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Maximum tolerated combination of radiosurgery and nivolumab plus or minus ipilimumab (Phase I)
Timeframe: Up to 100 days
Incidence of adverse event profile (Phase I)
Timeframe: Up to 100 days
Objective response rate (Phase II)
Timeframe: From the start of treatment through at least two years of follow-up
Objective radiological response (Phase II)
Timeframe: Up to 100 days